Activelle (Estradiol/Norethindrone Acetate)

Activelle Information:

Buy Activelle

Activelle (Estradiol/Norethindrone Acetate) is a hormone replacement therapy (HRT) used to manage menopausal symptoms such as hot flashes, night sweats, and vaginal dryness in postmenopausal women with intact uterus. It may also be used to prevent osteoporosis in postmenopausal women at high risk of fractures. It contains two active ingredients: estradiol, a form of estrogen, and norethindrone acetate, a progestin. As an HRT medication, Activelle replenishes estrogen levels in the body, alleviating menopausal symptoms. Estradiol compensates for the decreased production of estrogen. At the same time, norethindrone acetate protects the uterine lining from becoming too thick, which can happen when estrogen is taken alone.

Generic Activelle from Canada

Canada Drugs Online proudly serves you the brand Activelle, manufactured by Novo Nordisk from Canada. The generic Activelle is currently not available. Please call us toll-free at 1-877-900-3784 for details.

CanadaDrugsOnline.com also carries other Menopausal Hormone Therapies such as CombiPatch and Vagifem.

Activelle Side Effects:

Common mild side effects of this medication include acne, back and neck pain, mild abdominal pain, nausea, vomiting, bloating, breast tenderness, changes in menstrual flow, darkened skin, vaginal itching, headache, and weight changes. Contact your doctor if these common mild side effects don't spontaneously resolve or worsen.

Possible serious side effects of this medication include persistent nausea or vomiting, mental or mood changes, breast lumps, unusual vaginal bleeding, increased or new vaginal irritation, itching, odor or discharge, severe abdominal pain, yellowness of the eyes, dark urine, swelling of the hands, ankles, or feet, increased thirst and urination, chest, jaw, or left arm pain, unusual sweating, sudden or severe headache, weakness on one side of the body, confusion, trouble speaking, partial or complete blindness, pain, redness, or swelling of legs, tingling, weakness or numbness in the arms or legs, difficulty in breathing, coughing up blood, sudden dizziness or fainting, severe body itching and rash, and swelling of your face, lips, tongue, or throat. Stop this medication and seek immediate medical attention if you notice these severe side effects. Also, inform your doctor about other side effects you see that are not listed here.

Clinical studies show that Activelle is effective in treating menopausal symptoms like hot flashes and in preventing bone loss in postmenopausal women. It helps improve bone density and reduce hot flashes, with generally good short-term tolerance. However, like other hormone replacement therapies, Activelle carries an increased risk of adverse events such as the development of blood clots, stroke, and breast cancer. Safety studies suggest the need for personalized treatment, using the lowest effective dose for the shortest time needed.

Activelle Directions:

Activelle tablets should be taken orally as your doctor prescribes, typically one tablet daily. They can be taken with or without food, and it is recommended that you take the tablets at the same time each day to maintain consistent hormone levels. Do not take a double dose to make up for a missed one. Check out the leaflet on the medication pack for more instructions on its usage. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Activelle Precautions:

Before taking this medication, ensure you inform your doctor about any previous or current medical conditions you may have, including family history of certain medical conditions, especially the following:
• Allergic reaction to estradiol, norethindrone acetate, other ingredients of Activelle, or any other medication;
• Asthma;
• Blood clot disorders;
• Cancers of the breast, uterus, and ovaries;
• Diabetes, high blood pressure, high cholesterol;
• Dementia;
• Electrolyte imbalance, such as high calcium levels in the blood;
• Eye problems;
• Gallbladder diseases, such as gallstones;
• Heart disease, obesity, stroke;
• Kidney disease or liver disease;
• Mental disorders, such as dementia and depression;
• Migraine headaches;
• Seizures;
• Systemic lupus erythematosus;
• Unexplained vaginal bleeding;
• Underactive thyroid gland/hypothyroidism;
• Uterine problems, such as fibroids and endometriosis

Schedule follow-up visits with your doctor 3-6 months after commencing this medication and at least once a year after the first visit to assess your body's response to this medication. Do not smoke while using Activelle, as it can further increase the risk of developing adverse effects such as heart attack or pulmonary embolism. This medication can improve skin sensitivity to the sun and cause blotchy, dark areas. Therefore, proper precautions during sun exposure are always recommended, such as wearing protective clothing and sunscreen. This medicine should not be used by breastfeeding or pregnant women. It also should not be used by children.

Certain medications can interact with the active ingredients in Activelle and affect their actions in the body. Some of these drugs include:
• Drugs used for the treatment of epilepsy, such as phenobarbital, hydantoin, phenytoin, and carbamazepine;
• Drugs used for tuberculosis, such as rifampicin and rifabutin;
• Medications used for the treatment of HIV or hepatitis infections, such as nevirapine and efavirenz

Therefore, before taking this medication, you must inform your doctor about any medication you are currently taking, including herbal medicines and supplements, to determine if it can interact with Activelle.