Noxafil (Posaconazole)

Noxafil Information:

Buy Noxafil

Noxafil (Posaconazole) is used to prevent invasive aspergillus and candida infections in individuals who are immunocompromised and are at high risk of developing these infections, such as cancer patients and patients on immunosuppressive therapy following cell/organ transplant. It is also used to treat oropharyngeal candidiasis in patients who have not responded well to other antifungals such as fluconazole and itraconazole. Furthermore, it can also be used to treat other invasive fungal infections, such as fusariosis and zygomycosis. Noxafil's active ingredient is posaconazole, which belongs to the azole class of antifungal drugs. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Without ergosterol, the fungal cell membrane becomes weakened and permeable, leading to cell death. This action disrupts the growth and replication of fungal cells, ultimately treating the infection.

Generic Noxafil from Canada

Canada Drugs Online proudly serves you the brand Noxafil from Canada also called Posanol manufactured by Merck. The generic Noxafil is currently not available. Please call us toll-free at 1-877-900-3784 for details.

CanadaDrugsOnline.com also carries other Antifungal medications such as Cresemba and Jublia.

Noxafil Side Effects:

Common mild side effects of this medication include nausea, vomiting, diarrhea, headache, abdominal pain, dizziness, trouble sleeping, or stomach upset. Contact your doctor if these mild side effects persist or worsen.

Possible serious side effects of this medication include easy bruising and bleeding, weakness, muscle cramps, mental or mood changes, swelling of the ankles and feet, chills, fever, vaginal bleeding, shortness of breath, increased thirst and urination, fast, irregular heartbeat, severe dizziness, fainting, nausea and vomiting that doesn't stop, yellowness of the eyes and skin, dark urine, severe abdominal pain, severe body itching, rash, swelling of your face, lips, tongue, or throat, difficulty breathing, and dizziness. If you observe these severe side effects, discontinue this medication and seek immediate medical attention. Additionally, inform your doctor about any other side effects not listed here. Source

Clinical studies have shown that posaconazole is generally safe and effective for treating various fungal infections, particularly in immunocompromised patients. In clinical trials comparing it to other antifungal agents, it has demonstrated non-inferiority and, in some cases, superiority in efficacy. Its safety profile is also similar to other common antifungals. When used appropriately and monitored closely, Noxafil is considered an important therapeutic option for managing invasive fungal infections. The half-life of this medication typically ranges from approximately 15 to 35 hours. Source

Noxafil Directions:

This medicine is available as delayed-release tablets, which should only be swallowed whole and not chewed or crushed. Take this medication orally, with or without food, as directed by your doctor. Your doctor will determine the appropriate dose and duration of therapy for you based on your condition. To prevent toxicity, do not use more than the prescribed dose. Check out the leaflet in the medication pack for more details on usage. Store Noxafil at room temperature, away from light and moisture, and keep all medications away from children and pets.

Noxafil Precautions:

Before taking this medication, ensure you inform your doctor about any past or current personal or family history of medical conditions, especially the following:
• Allergic reactions to posaconazole, other ingredients of Noxafil, or any other medicine;
• Electrolyte imbalances, such as low levels of potassium or magnesium in the blood;
• Heart disease;
• Kidney disease;
• Liver disease;
• Severe diarrhea

Avoid smoking and the intake of alcohol and alcoholic beverages while taking this medication, as these substances can increase the risk of developing side effects, particularly liver toxicity. This medication can cause dizziness, so avoid driving, operating machinery, or performing other potentially hazardous tasks until you know how you are affected by this medication. This medication should be used with caution in older adults as they may be more sensitive to the side effects of this drug. Consult your doctor before using this medication during pregnancy or while breastfeeding. This medication is not recommended for use in children younger than two years. Posaconazole can interact with various other medications, thereby increasing the risk of developing side effects. Some of these other medications include:
• Alpha blockers such as alfuzosin, silodosin;
• Ergot alkaloids such as ergotamine, dihydroergotamine;
• Lipid-lowering drugs such as lovastatin and simvastatin;
• Seizure medicines such as phenytoin;
• Sirolimus;
• Venetoclax

Therefore, before using this medication, inform your doctor about any other medications you are currently taking, including herbal medicines and supplements, to determine if it is safe to use along with Noxafil.