Combivir (Zidovudine/Lamivudine)

Combivir Information:

Buy Combivir

Combivir (Zidovudine/Lamivudine) is used to treat HIV infection and slow down the progression of the disease. It's typically used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) to effectively manage HIV infection. Its active ingredients are zidovudine (AZT) and lamivudine. Both of these drugs belong to the class of antiretroviral medications known as nucleoside reverse transcriptase inhibitors (NRTIs). Zidovudine works by inhibiting the action of the enzyme reverse transcriptase, which is essential for HIV replication. Similarly, lamivudine also inhibits the reverse transcriptase enzyme but through a slightly different mechanism. It competes with natural nucleosides that the virus needs to replicate, thereby interfering with viral DNA synthesis. Together, both active ingredients in Combivir work synergistically to suppress HIV replication, lower viral load, and slow down the progression of HIV infection.

Generic Combivir from Canada

Canada Drugs Online is proud to offer you the generic Combivir from Canada. The brand version is not available. Please call us toll-free at 1-877-900-3784 for details.

CanadaDrugsOnline.com also carries other HIV/AIDS Medications such as Atripla and Epivir.

Combivir Side Effects:

Common mild side effects of this medication include altered sense of taste, dizziness, fatigue, nausea, hair loss, headache, itching, loss of appetite, and stomach upset. Contact your doctor if these mild side effects persist or worsen.

Possible serious side effects of this medication include fever, chills, or sore throat, increased frequency of infections, muscle tenderness and weakness, dizziness, pale skin, unusual tiredness, nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding, poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide, numbness or weakness in the hands and feet spreading to the trunk, pounding heartbeat, chest pain, persistent nausea and vomiting, abdominal pain, diarrhea, tingling, burning, numbness, or pain in the hands, arms, feet, or legs, seizures, severe body itching, rash, swelling of your face, lips, tongue, or throat, difficulty in breathing and dizziness. Discontinue this medication and seek immediate medical attention if you observe these severe side effects. Additionally, inform your doctor about any other side effects not listed here. Source

A randomized clinical study showed the combination of lamivudine and zidovudine to be more effective in reducing viral load and providing a more sustained increase in the levels of CD4+ cells count when compared with zidovudine monotherapy. It is also generally well tolerated by most individuals. However, regular monitoring by healthcare providers is recommended to ensure both safety and efficacy in managing HIV infection. Generally, the half-life of zidovudine is around 1 hour, while the half-life of lamivudine is approximately 5 to 7 hours. (Source)

Combivir Directions:

Combivir tablets should be taken orally with or without food. The generally recommended dose is one tablet twice daily, 12 hours apart. However, consult your doctor for the appropriate dose for you as it may be influenced by various factors such as coexisting medical conditions. Take this medication regularly as prescribed by your doctor for maximum effectiveness and avoid taking more than the prescribed dose. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Combivir Precautions:

Before taking this medication, ensure you inform your doctor about any past or current personal or family history of medical conditions, especially the following:
• Allergic reaction to zidovudine, lamivudine, other ingredients of Combivir, or any other medication;
• Blood cell disorders such as anemia, reduced white blood cell count;
• Chronic alcohol use;
• Kidney disease;
• Liver disease including viral hepatitis;
• Pancreatic problems such as pancreatitis

Avoid consuming alcohol and smoking cigarettes while taking this medication, as these substances can increase the risk of side effects. This medication can cause dizziness, drowsiness, or difficulty in concentrating, so avoid driving or operating heavy machinery until you know how the medication affects you. Combivir should be used with caution in children as they are at higher risk of developing side effects. This medication should not be used during pregnancy unless the benefits outweigh the risks. Women living with HIV infection should not breastfeed because of the risk of passing HIV to a baby who does not have the infection. This medication is not recommended for use in children younger than 12 years or individuals weighing less than 30 kg. Some medications can interact with the active ingredients in Combivir, leading to unwanted side effects or reduced effectiveness. Some of these drugs include:
• Acyclovir;
• Cimetidine;
• Cladribine;
• Clarithromycin;
• Doxorubicin;
• Mesalamine;
• Methadone;
• Valproic acid

Therefore, you must inform your healthcare provider about all the medications, including herbal medications and supplements, that you are taking before starting Combivir to prevent drug interactions.